A meta-analysis on the susceptibility to the development of bladder cancer in the presence of DNMT3A, DNMT3B, and MTHFR gene polymorphisms

Abstract Background The etiology of bladder cancer is not yet well known. In this study, we want to evaluate the effect polymorphisms genes that have an epigenetic ( MTHFR, DNMT3A/B ) on susceptibility develop (BC). Methods A systematic review was performed for DNMT3A, and DNMT3B , followed by a meta-analysis conducted rs1801131, rs1801133, rs2274976, rs1550117, rs1569686 SNPs. sensitivity subgroup analysis were then used. Results 20 studies included, where no statistically significant association between any analyzed SNPs occurrence BC detected. Subgroup revealed in North African population with rs1801133: TT vs . TC + CC P = 0.013; OR 95% CI 0.52 [0.311–0.872]); .TC 0.003; 0.448 [0.261–0.769]) American rs1801131: CA 0.039; 0.71 [0.523–0.984]). there rs1801131 (OR 0.79, 95%CI [0.65–0.97]), 0.80, [0.65–0.98]) 0.78, [0.63–0.96]) which correspond AA; vs. CA; AA genetic models. Conclusion This first study assess DNMTs risk. No found MTHFR DNMT3A / B development, except populations rs1801133 respectively, protective based analysis.